Opening Welcome Session
- Introduction of overall meeting themes and goals (Yulin Ge)
- Introduction speakers and talk titles (Thomas Wisniewski)
- Journal of Aging and Disease, ISOAD & Special Issues (Kunlin Jin)
Keynote talks
Clint Wright NIH – Keynote opening
NINDS Perspectives on Postmortem Imaging and Neuropathology
Julie Schneider Rush University - Keynote closing
Integrating Pathology and Imaging toward advances in Hippocampal Sclerosis of Aging
S1. In vivo breakthroughs and unmet needs
Adam Brickman Columbia University
Tentative: White Matter Lesion Heterogeneity: What Is Established and What Remains Unclear
Hanzhang Lu John Hopkins University
An overview of in vivo imaging biomarkers of VCID: Progress and Gaps
Yulin Ge NYU Grossman SOM
Choroid plexus imaging and histopathology in aging & dementia
Laura E. Jonkman Amsterdam UMC
Best of both worlds: combining neuroimaging and neuropathology in AD and related dementias.
S2. Ex vivo MRI: Imaging Protocol, PMI, Fixation Effects
Claudia Lenz University of Basel, Switzerland
From biophysics to bias: How temperature, PMI, and fixation shape postmortem MRI
Andre Van Der Kouwe Harvard Medical School
Ultra-High Resolution Ex Vivo MRI: The 100 μm Dataset in Aging and Dementia
S3. Multi-modal and Multi-scale Imaging Registration
Michael Miller John Hopkins University
Post-mortem MRI and digital pathology
Michael Zeineh Stanford University
Precise MRI-SLI-histology coregistration of paraffin-embedded tissue
James Gee UPenn SOM
Implicit Optimization Enhances Feature Learning for Multimodal and Multiscale Deformable Registration
S4. Histopathological Discoveries in Dementia
Thomas Wisniewski NYU Grossman SOM
Early Neuropathological Markers of AD/ADRD
John Crary Mount Sinai School of Medicine
Mechanisms of tauopathy & brain aging: novel approaches in the age of AI & brain organoids
Rachel Bennett Harvard Medical School
Tentative: Vascular and tau pathology in human tissues
Julia Kofler University of Pittsburgh
Tentative: ARIA Pathology
S5. Advanced MRI and Histopathology Tools for Postmortem Research
C. Dirk Keene University of California at San Diego
Advanced histology staining and brain tissue processing and analysis techniques including proteomics
Susie Huang Harvard Medical School
Mesoscale diffusion MRI of the human brain on Connectome 2.0: Bridging in vivo imaging, ex vivo MRI, and neuropathology in dementia
Beatrix Ueberheide NYU Grossman SOM
Tentative: Mass Spectrometry Proteomics for Identifying AD Pathology
Youssef Zaim Wadghiri NYU Grossman SOM
From Whole Organ to Cellular Detail: Hardware Innovation and In-House Design for Multiscale MR Microscopy
S6. Imaging – Pathology Correlations
Jean Augustinack Harvard Medical School
Tau vulnerability and its proximity to vasculature, linking histology and imaging
Paul Yushkevich UPenn SOM
MRI-Guided Histology for Postmortem MRI-Pathology Studies in Alzheimer’s Disease
Yi Wang Weill Cornell Medicine
QSM study of tissue magnetism changes associated with dementia.
Mahir Tazwar Rush University
Integrating multimodal postmortem and antemortem MRI features to detect LATE-NC in-vivo
Valentina Perosa Harvard Medical School
Relationship between Cerebral Small Vessel Disease and Proteinopathies in the Medial Temporal Lobe or Neuroimaging-pathological correlates of CAA
S7. Dementia Subtypes and Insights from Postmortem research
Andrew F. Teich Columbia University
Subtyping and co-pathology in Alzheimer’s disease: insights from autopsy studies
Carlos Faraco NIH
Tentative: NIH AD/ADRD Initiatives
Jennifer Frontera NYU Grossman SOM
Tentative: Neuropathology of COVID-19.
Breton Asken University of Florida
Tentative: Recent updates on chronic traumatic encephalopathy (CTE)